Is oxybutynin sedating
Medicines with anticholinergic and sedative properties are widely prescribed for older people in Australia.
The likelihood that medicines may produce unwanted central anticholinergic effects depends in part on age related and patient specific variability in pharmacokinetic parameters, bloodbrain barrier permeability, degree of cholinergic neuronal degeneration and a patient's baseline cognitive status.
In 932 community dwelling people aged more than 65 years in the Women's Health and Aging Study conducted in the United States, use of medicines with anticholinergic properties was associated with difficulties in balance and mobility.* New medicine: reported adverse effects profile is consistent with moderate anticholinergic effects ** Not included on the schedule of PBS/RPBS benefits *** Found in cold and flu treatments, may be purchased over-the-counter Reproduced from Veterans' MATES Therapeutic brief 25.
Patients may benefit from clinicians reviewing the anticholinergic load of the current medicine regimen before the initiation of cholinesterase inhibitors or memantine.Dispensing of anticholinergic medicines also increased following initiation of cholinesterase inhibitors.Some of these anticholinergic medicines may have been prescribed to treat the adverse effects of the cholinesterase inhibitor (eg. Patients may benefit from clinicians reviewing the anticholinergic load of their current medicine regimen before initiating cholinesterase inhibitors or memantine, with the aim of minimising or ceasing medicines with anticholinergic properties.Older people with dementia may be particularly susceptible to cognitive impairment associated with anticholinergic and sedative medicines.This impairment may be misattributed to the disease process itself.